Scientists are doing a lot of work with the genes of Life these days. One thing that fascinates me, is the discovery that one way genes work in our bodies, is to turn on ~ or off ~ certain functions, and predilections for disease or illness.
Because I also believe in the 'Power of the Word', I practice, self-healing, and the renewing of my body, simply by declaring the perfect functioning, and wholeness of my cells, tissues and complete body system. So knowing that my body will listen and respond to what I tell it and declare about it's state, I get really excited that scientists are determining what part of the brain or body I need to be visualizing and directing my attention to, when speaking the word. Oh yes, metaphysical work going on here. The alchemist(doctor/healer) is In!
I'm interpreting this, that we can speak to our genetic make-up, and direct it to make connections, that create new neuronal networks and release the chemicals that are needed within our body to create greater health and well-being. We can also close circuits that may pour too much of certain chemicals into the mix, and create emotional and physical havoc in our systems.
No I'm not crazy....You just have to have been hanging out in the realm of Infinite Possibilities as long as I have (smile). I've also been naming myself, a "magnet for the Best in Life" for many many years, and this has resulted in pulling really deep and wonderful transforming information to me, from everywhere, and out of all types of disciplines. I trust this Inner Magnet's great love for Life as me.
Bear with me a bit more. You know I haven't shared my thoughts with you much lately. I've just been 'throwing up articles', so I hope you'll not begrudge me sharing these connections and revelations I'm receiving.
Right now America, is all up in arms about the amount of guns that are truly warfare weapons, that are amassed throughout the population. The murders of the innocent Sandy Hook schoolchildren a few months ago, has been followed each week, by some headline news of more multiple murders that are senseless killings. No one wants to go to the heart of the matter, which is that it's the 'thinking', concepts and belief system of American culture that is at the root of this madness.
This past weekend, Chris Kyle, a man who held the reputation of being the most lethal sniper in the United States military history, with 160 confirmed kills, (out of 255 claimed) was himself killed, while trying to be of support to Ray Routh, a young troubled former Marine.
After leaving the military, besides writing a best selling book, Kyle had formed an organization that provids support and counseling for troubled veterans. Routh's mother had asked for help with her son. So to get acquainted, Kyle and a friend took Routh to a shooting range for target practice, and there Routh shot them both dead and stole Kyle's truck.
According to the New York Times, five months earlier, police officers were called to Routh's home. "Officers found him near his home, shirtless and shoeless, and he told them he was a Marine veteran with post-traumatic stress disorder, the report said. His mother told officers that he had been drinking and had become upset when his father told him he was going to sell his gun. Mr. Routh was taken into protective custody and transported to a Dallas psychiatric hospital."
I digress here, because post-traumatic stress disorder is a serious problem in American society. And it is not only traumatic stress brought on by the experiences of war-related military service. Traumatic experiences haunt and stun many of us into a stunted, dazed and confused mindset, about our worthiness, existence and our right place in the world. What is saddest, is the duration and the intensity of suffering that can last a lifetime. And I'm sure, it can be passed on, in someway through our genes and socialization to future generations.
Think of the experience of Native Americans, and the Japanese Americans, or Chinese immigrant workers. I particularly am grateful for the work of Dr. Joy DeGruy Leary on how the effects of the experience of slavery still permeate, perculate and influence the lives and reactions of both African American and white people today. Many have found her research and book, Post Traumatic Slave Syndrome quite illuminating.
Okay~
Enough of the digression. I'm reminded that my purpose is to inspire and elevate the Good that it's more visable to all. So let me get right to it with this really interesting article below that talks of the research being done that can help us to be even more resilliant in the face of traumatic events.
Read the article to the end, and see what your Heart of Love/Intelligence pulls out for you to hold onto. Be still and get quiet, because there's riches in the silence and truth in the depths. You know how it's said that we human beings only use a portion of the power of our brain? There's alot of interesting information in the article about how our mind works . See what's of value to you, that can be reflected back into your Life.
I challenge you to be imaginative in the ways you can 'play' with any 'gems'. Then practice regularly applying the 'Good knewz' within your Life and experience.
lovu,
Kentke
Nature International Weekly Journal of Science
Stress: The Roots of Resilience
Most people bounce back from trauma — but some never recover. Scientists are trying to work out what underlies the difference.
By Virginia Hughes
October 2012
Elizabeth Ebaugh is finally comfortable visiting the
bridge from which she was thrown 26 years ago.
On a chilly, January night in 1986, Elizabeth Ebaugh carried a bag of groceries across the quiet car park of a shopping plaza in the suburbs of Washington DC. She got into her car and tossed the bag onto the empty passenger seat. But as she tried to close the door, she found it blocked by a slight, unkempt man with a big knife. He forced her to slide over and took her place behind the wheel.
The man drove aimlessly along country roads, ranting about his girlfriend's infidelity and the time he had spent in jail. Ebaugh, a psychotherapist who was 30 years old at the time, used her training to try to calm the man and negotiate her freedom. But after several hours and a few stops, he took her to a motel, watched a pornographic film and raped her. Then he forced her back into the car.
She pleaded with him to let her go, and he said that he would. So when he stopped on a bridge at around 2 a.m. and told her to get out, she thought she was free. Then he motioned for her to jump. “That's the time where my system, I think, just lost it,” Ebaugh recalls. Succumbing to the terror and exhaustion of the night, she fainted.
Ebaugh awoke in freefall. The man had thrown her, limp and handcuffed, off the bridge four storeys above a river reservoir. When she hit the frigid water, she turned onto her back and started kicking. “At that point, there was no part of me that thought I wasn't going to make it,” she says.
Few people will experience psychological and physical abuse as terrible as the abuse Ebaugh endured that night. But extreme stress is not unusual. In the United States, an estimated 50–60% of people will experience a traumatic event at some point in their lives, whether through military combat, assault, a serious car accident or a natural disaster. Acute stress triggers an intense physiological response and cements an association in the brain's circuits between the event and fear. If this association lingers for more than a month, as it does for about 8% of trauma victims, it is considered to be post-traumatic stress disorder (PTSD). The three main criteria for diagnosis are recurring and frightening memories, avoidance of any potential triggers for such memories and a heightened state of arousal.
Ebaugh experienced these symptoms in the months after her attack and was diagnosed with PTSD. But with the help of friends, psychologists and spiritual practices, she recovered. After about five years, she no longer met the criteria for the disorder. She opened her own private practice, married and had a son.
About two-thirds of people diagnosed with PTSD eventually recover. “The vast majority of people actually do OK in the face of horrendous stresses and traumas,” says Robert Ursano, director of the Center for the Study of Traumatic Stress at the Uniformed Services University of the Health Sciences in Bethesda, Maryland. Ursano and other researchers want to know what underlies people's mental strength. “How does one understand the resilience of the human spirit?” he asks.
Since the 1970s, scientists have learned that several psychosocial factors — such as strong social networks, recalling and confronting fears and an optimistic outlook — help people to recover. But today, scientists in the field are searching for the biological factors involved. Some have found specific genetic variants in humans and in animals that influence an individual's odds of developing PTSD. Other groups are investigating how the body and brain change during the recovery process and why psychological interventions do not always work. The hope is that this research might lead to therapies that enhance resilience.
A natural response
Although no one can fully understand what was going on in Ebaugh's mind during her attack, scientists have some idea of what was happening to her body. As soon as Ebaugh saw her attacker and his knife, her brain's pituitary gland sent signals to her adrenal glands, atop the kidneys, to start pumping out the stress hormones adrenaline and cortisol. In turn, her pulse quickened, her blood pressure rose and beads of sweat formed on her skin. Her senses sharpened and her neural circuits formed strong memories, so that if she ever encountered this threat in the future, she would remember the fear and flee.
The repercussions were profound. For the first week after the abduction, “I felt like a newborn baby”, Ebaugh says, “like I had to be held, or at least be in the presence of somebody”. She shivered constantly, was easily startled and felt only fear. She could not go near the grocery store.
Nearly every trauma victim experiences PTSD symptoms to some degree. Many people who are diagnosed with the disorder go on to have severe depression, substance-abuse problems or suicidal thoughts. PTSD can take a horrific toll. Between 2005 and 2009, as a growing number of soldiers faced multiple deployments in Iraq and Afghanistan, suicide rates in the US Army and Marines nearly doubled.
Expand
Over the past two decades, researchers have used various kinds of imaging techniques to peer inside the brains of trauma victims. These studies report that in people with PTSD, two areas of the brain that are sensitive to stress shrink: the hippocampus, a deep region in the limbic system important for memory, and the anterior cingulate cortex (ACC), a part of the prefrontal cortex that is involved in reasoning and decision-making. Functional magnetic resonance imaging (fMRI), which tracks blood flow in the brain, has revealed that when people who have PTSD are reminded of the trauma, they tend to have an underactive prefrontal cortex and an overactive amygdala, another limbic brain region, which processes fear and emotion (see 'The signature of stress').People who experience trauma but do not develop PTSD, on the other hand, show more activity in the prefrontal cortex. In August1, Kerry Ressler, a neuroscientist at Emory University in Atlanta, Georgia, and his colleagues showed that these resilient individuals have stronger physical connections between the ACC and the hippocampus. This suggests that resilience depends partly on communication between the reasoning circuitry in the cortex and the emotional circuitry of the limbic system. “It's as if [resilient people] can have a very healthy response to negative stimuli,” says Dennis Charney, a psychiatrist at the Mount Sinai School of Medicine in New York, who has conducted several brain-imaging studies of rape victims, soldiers and other trauma survivors.
Environmental protection
After her abduction, Ebaugh began seeing a psychotherapist and several alternative-medicine practitioners. But more than anything else, she attributes her resilience to being surrounded by caring people — beginning within minutes of her escape.
After Ebaugh crawled up the rocky riverbank, a truck driver picked her up, took her to a nearby convenience store and bought her a cup of hot tea. Police, when they arrived, were sympathetic and patient. The doctor at the hospital, she says, treated her like a daughter. A close friend took her in for a time. And her family offered reassurance and emotional support. “For the first month, I almost had to tell people to stop coming because I was so surrounded by friends and community,” she says.
Studies of many kinds of trauma have shown that social support is a strong buffer against PTSD and other psychological problems. James Coan, a psychologist at the University of Virginia in Charlottesville, has done a series of experiments in which women lie in an fMRI scanner and see 'threat cues' on a screen. They are told that between 4 and 10 seconds later, they may receive a small electric shock on the ankle. The cue triggers sensory arousal and activates brain regions associated with fear and anxiety, but when the women hold the hands of their husbands or friends, these responses diminish.
Social interactions are complex and involve many brain circuits and chemicals; no one knows exactly why they provide relief. Being touched by someone is thought to stimulate the release of natural opioids, such as endorphins, in the brain. The ACC is packed with opioid receptors, suggesting that touch could influence its response to stress.
Other clues come from the hormone oxytocin, which courses through the brain during social interaction and has been shown to boost trust and reduce anxiety. In one imaging study4, participants viewed frightening images after receiving nasal sprays of either oxytocin or a placebo. Those who sniffed oxytocin showed reduced activation in the amygdala and weaker connections between the amygdala and the brainstem, which control some stress responses, such as heart rate. The oxytocin surge that comes from being around other people could, like endorphins, help to reduce the stress response.
Past social interactions may also affect how a person responds to trauma. Chronic neglect and abuse unquestionably lead to a host of psychological problems and a greater risk of PTSD. Ressler, however, points to a factor that is well recognized but poorly understood: 'stress inoculation'. Researchers have found that rodents5 and monkeys6, at least, are more resilient later in life if they experience isolated stress events, such as a shock or a brief separation from their mothers, early in infancy.
Ebaugh says that early stress — and the confidence she gained in conquering it — helped her to recover from her traumatic abduction. She was born with a condition that made her feet turn inwards. At age ten, she underwent surgery to rebuild her knees followed by a year of intensive rehabilitation. “It wasn't foreign to me to be hurt and have to walk the walk of being strong again,” she says. “It's like a muscle, I think, that gets built up.”
Resilient by nature
Although most people, like Ebaugh, recover from trauma, some never do. Some scientists are seeking explanations for such differences in the epigenome, the chemical modifications that help to switch genes on and off. Others are looking in the genes themselves. Take, for example, FKBP5, a gene involved in hormonal feedback loops in the brain that drive the stress response. In 2008, Ressler and his colleagues showed that in low-income, inner-city residents who had been physically or sexually abused as children, certain variants in FKBP5 predisposed them to developing PTSD symptoms in adulthood. Other variants offered protection.The most talked-about biological marker of resilience is neuropeptide Y (NPY), a hormone released in the brain during stress. Unlike the stress hormones that put the body on high alert in response to trauma, NPY acts at receptors in several parts of the brain — including the amygdala, prefrontal cortex, hippocampus and brainstem — to help shut off the alarm. “In resiliency, these brake systems are turning out to be the most relevant,” says Renu Sah, a neuroscientist at the University of Cincinnati in Ohio.
Interest in NPY and resilience took off in 2000, partly because of a study of healthy US Army soldiers who participated in a survival course designed to simulate the conditions endured by prisoners of war, such as food and sleep deprivation, isolation and intense interrogations8. NPY levels went up in the soldiers' blood within hours of the interrogations. Special Forces soldiers who had trained to be resilient had significantly higher NPY levels than typical soldiers.
Researchers are now conducting animal experiments to study how NPY works. In one experiment, a team at the Indiana University School of Medicine in Indianapolis restrained a rat in a tight-fitting plastic pouch for 30 minutes, then released it into a box with another rat9. The restraint made the rat so anxious that it avoided interacting with the other animal for 90 minutes. But when rats were injected with NPY before the treatment, they interacted with cage-mates as if nothing had happened.
The work could lead to treatments. Charney's group at Mount Sinai is carrying out a phase II clinical trial of an NPY nasal spray for individuals with PTSD. Others are investigating small molecules that can cross the blood–brain barrier and block certain receptors that control NPY release.
Click here, then zoom in to read this graphic:
http://www.nature.com/news/stress-the-roots-of-resilience-1.11570
Conflict resolution
The US military is leading the hunt for additional biological markers of resilience. Since 2008 — driven in part by soaring suicide rates among soldiers — the US Army has collaborated with the National Institute of Mental Health and several academic institutions on a US$65-million project called Army STARRS (the Study to Assess Risk and Resilience in Servicemembers). The project has many parts, including a retrospective look at de-identified medical and administrative records for 1.6 million soldiers, in search of early warnings of suicide, PTSD and other mental-health problems. STARRS scientists are also collecting data — such as blood samples, medical histories and cognitive testing results — on tens of thousands of current soldiers. The researchers expect to publish their first findings early next year.
The military also funds research into animal models of resilience. Most rodents will quickly learn to associate painful foot shocks with a certain cue, such as a tone or a specific cage. After they have learned the association, the rodents freeze on experiencing the cue, even without the shock. Several years ago, Abraham Palmer, a geneticist now at the University of Chicago in Illinois, made a line of resilient mice by selectively breeding mice that froze for abnormally short periods of time. After about four generations, he had mice that froze for about half the time of typical animals10. The effect was not due to a difference in pain sensitivity or general learning ability. This month, Luke Johnson, a neuroscientist at the Uniformed Services University, will present data at the Society for Neuroscience meeting in New Orleans, Louisiana, showing that these mice have uncommonly low activity in the amygdala and hippocampus, consistent with human studies of PTSD resilience. They also have low levels of corticosterone, a stress hormone, in their urine.
“They have a quieter system, even at rest,” says Johnson. “It suggests that there are underlying biological traits that are associated with the capacity of the animal for fear memory.” In future experiments, Johnson plans to use the mice to study NPY and potential new therapies.
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